Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

被引：9
|
作者：
Hang, Meng [1 ]
Zhao, Fan [1 ]
Chen, Shu-Bo [1 ]
Sun, Qing [1 ]
Zhang, Chun-Xiao [1 ]
机构：
[1] Jiangsu Prov Wuxi 2 Peoples Hosp, Dept Oncol, Wuxi 214002, Peoples R China
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2015年 / 10卷 / 02期
关键词：
Epithelial-Mesenchymal Transition; Kaempferol; Non-small cell lung cancer; CARCINOMA; APOPTOSIS; FLAVONOIDS; FIBROSIS;
D O I：
10.3329/bjp.v10i2.21739
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.
引用
收藏
页码：267 / 270
页数：4
相关论文
共 50 条
  • [1] Epithelial-mesenchymal transition and brain metastasis in non-small cell lung cancer
    Goodgame, B. W.
    Young, D. S.
    Haley, J.
    Mark, W.
    Govindan, R.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [2] Epithelial-mesenchymal transition in non-small cell lung cancer
    Soltermann, A.
    [J]. PATHOLOGE, 2012, 33 : 311 - 317
  • [3] Salinomycin Overcomes Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition
    Hwang, K.
    Oh, S.
    Kim, H.
    Jeong, E.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [4] Topotecan inhibits metastasis of non-small cell lung cancer by regulating epithelial-mesenchymal transition
    Liu, Zhen
    Guo, Lvqian
    Yin, Panpan
    Zhang, Feng
    Song, Wenjuan
    Gao, Junling
    Li, Xinran
    Teng, Yuou
    Yu, Peng
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2022, 5
  • [5] Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial-mesenchymal transition
    Deng, Qiu-di
    Lei, Xue-Ping
    Zhong, Yi-Hang
    Chen, Min-Shan
    Ke, Yuan-Yu
    Li, Zhan
    Chen, Jing
    Huang, Li-Juan
    Zhang, Yu
    Liang, Lu
    Lin, Zhong-Xiao
    Liu, Qing
    Li, Song-Pei
    Yu, Xi-Yong
    [J]. ACTA PHARMACOLOGICA SINICA, 2021, 42 (09) : 1486 - 1497
  • [6] Epithelial-mesenchymal transition changes in smokers with non-small cell lung cancer
    Lu, W.
    Chia, C.
    Larby, J.
    Haug, G.
    Hardikar, A.
    Singhera, G.
    Hackett, T.
    Robertson, I
    Eapen, M.
    Sohal, S.
    [J]. RESPIROLOGY, 2023, 28 : 56 - 57
  • [7] Epithelial-Mesenchymal Transition Contributes to Docetaxel Resistance in Human Non-Small Cell Lung Cancer
    Shen, Weiwei
    Pang, Hailin
    Liu, Jiayu
    Zhou, Jing
    Zhang, Feng
    Liu, Lele
    Ma, Ningqiang
    Zhang, Ning
    Zhang, Helong
    Liu, Lili
    [J]. ONCOLOGY RESEARCH, 2014, 22 (01) : 47 - 55
  • [8] CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells
    Lu, Xiangdong
    Gao, Juan
    Zhang, Yao
    Zhao, Tao
    Cai, Hongchuan
    Zhang, Tingrong
    [J]. PLOS ONE, 2018, 13 (07):
  • [9] MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer
    Cai, Yanjun
    Ruan, Jian
    Yao, Xueqing
    Zhao, Liang
    Wang, Baocheng
    [J]. ONCOLOGY REPORTS, 2017, 37 (05) : 2787 - 2794
  • [10] The role of alternative polyadenylation in epithelial-mesenchymal transition of non-small cell lung cancer
    Wu, Sijia
    Qin, Xinyu
    Huang, Liyu
    [J]. HUMAN MOLECULAR GENETICS, 2024, 33 (08) : 677 - 686
12345