Introduction: the university libraries are constituted as a key space to fulfill the educational, investigative and linking objectives of universities and higher education centers. The irruption and extensive use of technology has impacted the daily life of libraries, forcing them to implement new processes of automation and innovation. The Integrated Library Systems are presented as cutting-edge solutions to improve obsolete library services. However, when designing one of these systems, flaws are evident regarding the factors on which greater efforts must be focused for its successful production. Based on this problem, the study tries to identify the key factors for the design of Integrated Library Systems Method: the study uses the Matrix of Cross Impact Multiplications Applied to Classification or MICMAC method to generate a Structural Analysis. Results: the result established that the factors: intuitive design, flexibility, interconnection, and portability are the key factors for the design of integrated library systems in universities. Conclusion: the key factors identified can guarantee educational centers success, with efficiency and money savings, in their path to the design of integrated library management systems.