DEVELOPMENT AND VALIDATION OF A METHOD FOR THE ANALYSIS OF TETRACYCLINES IN CHICKEN-MUSCLE BY LIQUID CHROMATOGRAPHY-ELECTROSPRAY-MASS SPECTROMETRY IN TANDEM (LC-ESI-MS/MS)

被引：8
|
作者：
Uekane, Thais Matsue [1 ]
Aquino Neto, Francisco Radler [1 ]
Gomes, Luiz Nelson F. [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Quim, BR-21941909 Rio De Janeiro, Brazil
来源：
QUIMICA NOVA | 2011年 / 34卷 / 01期
关键词：
tetracyclines; chicken-muscle; validation; RESIDUAL TETRACYCLINES; CONFIRMATORY METHOD; ANIMAL-TISSUES; ANTIBIOTICS; BOVINE; EXTRACTION; PRODUCTS; CHLORTETRACYCLINE; FLUOROQUINOLONES; OXYTETRACYCLINE;
D O I：
10.1590/S0100-40422011000100009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A LC-ESI-MS/MS method was developed and validated according to the European Union decision 2002/657/EC, for the determination of tetracyclines (TCs) in chicken-muscle since Europe is one of the main markets for Brazilian products. Linearity of r > 0.9979, limits of quantification in the range of 7.0-35.0 ng/g, average recoveries of 89.38 - 106.27%, within-day and between-day precision were adequate for all TCs. The decision limit and the detection capability were 93.00-106.46 ng/g and 95.84-114.38 ng/g, respectively. This method is suitable for application in surveillance programmes of residues of TCs in chicken-muscle samples.
引用
收藏
页码：43 / 48
页数：6
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