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SOX2 functions in adult neural stem cells

被引：201
|
作者：
Episkopou, V [1 ]
机构：
[1] Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England
来源：
TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.tins.2005.03.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sox2 is expressed highly in the neuroepithelium of the developing CNS and has been shown to function in neural stem cells. Because Sox2-null mutant mice fail to develop beyond implantation, the role of SOX2 in the CNS has lacked validation. A new genetic model addresses the role of SOX2 in the adult brain and provides evidence that it is involved in the maintenance of neurons in specific regions, in the proliferation and/or maintenance of neural stem cells, and in neurogenesis.
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页码：219 / 221
页数：3
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