Race and prostate cancer: genomic landscape

被引：14

作者：

Arenas-Gallo, Camilo ^{[1
]}

Owiredu, Jude ^{[2
]}

Weinstein, Ilon ^{[1
]}

Lewicki, Patrick ^{[2
]}

Basourakos, Spyridon P. ^{[2
]}

Vince, Randy, Jr. ^{[3
]}

Al Awamlh, Bashir Al Hussein ^{[2
,4
]}

Schumacher, Fredrick R. ^{[5
,6
]}

Spratt, Daniel E. ^{[7
]}

Barbieri, Christopher E. ^{[2
]}

Shoag, Jonathan E. ^{[1
,2
,6
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Urol, Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA

[2] Weill Cornell Med, Dept Urol, NewYork Presbyterian Hosp, New York, NY 10021 USA

[3] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[4] Vanderbilt Univ, Dept Urol, Med Ctr, Nashville, TN USA

[5] Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA

[6] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Sch Med, Dept Radiat Oncol, Univ Hosp Seidman Canc Ctr, Cleveland, OH USA

来源：

NATURE REVIEWS UROLOGY | 2022年 / 19卷 / 09期

关键词：

DIFFERENTIALLY METHYLATED GENES; AFRICAN-AMERICAN; HIGH-GRADE; HEALTH DISPARITIES; GERMLINE MUTATIONS; INTRAEPITHELIAL NEOPLASIA; DNA HYPOMETHYLATION; PROGNOSTIC VALUE; ERG ONCOPROTEIN; SPOP MUTATIONS;

D O I：

10.1038/s41585-022-00622-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this Review, the authors discuss racial differences in the prevalence of genetic mutations in the main molecular drivers of prostate cancer and provide input regarding the role of genomics in racial disparities observed in prostate cancer outcomes. In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integrative genomics approaches enabled researchers to characterize the genetic and epigenetic landscape of prostate cancer and to define different molecular subclasses based on the combination of genetic alterations, gene expression patterns and methylation profiles. Several molecular drivers of prostate cancer have been identified, some of which are different in men of different races. However, the extent to which genomics can explain racial disparities in prostate cancer outcomes is unclear. Future collaborative genomic studies overcoming the underrepresentation of non-white patients and other minority populations are essential.

引用

页码：547 / 561

页数：15

共 50 条

[1] Race and prostate cancer: genomic landscape
Camilo Arenas-Gallo
Jude Owiredu
Ilon Weinstein
Patrick Lewicki
Spyridon P. Basourakos
Randy Vince
Bashir Al Hussein Al Awamlh
Fredrick R. Schumacher
Daniel E. Spratt
Christopher E. Barbieri
Jonathan E. Shoag
[J]. Nature Reviews Urology, 2022, 19 : 547 - 561
[2] The Genomic Landscape of Prostate Cancer
Spans, Lien
Clinckemalie, Liesbeth
Helsen, Christine
Vanderschueren, Dirk
Boonen, Steven
Lerut, Evelyne
Joniau, Steven
Claessens, Frank
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (06) : 10822 - 10851
[3] Ancestral Characterization of the Genomic Landscape in Prostate Cancer
不详
[J]. CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2021, 19 (08) : 12 - 13
[4] Comprehensive Genomic Profiling of Cell-Free DNA in Men With Advanced Prostate Cancer: Differences in Genomic Landscape Based on Race
Zimmerman, Raquel
Bilen, Mehmet A.
Heath, Elisabeth, I
Nandagopal, Lakshminarayanan
Swami, Umang
Kessel, Adam
Jaeger, Ellen
Wesolowski, Sergiusz
Hernanadez, Edgar J.
Chipman, Jonathan
Mack, Alleda
Ravindranathan, Deepak
Maughan, Benjamin L.
Nussenzveig, Roberto
Yandell, Mark
Kohli, Manish
Lilly, Michael B.
Sartor, A. Oliver
Agarwal, Neeraj
Barata, Pedro C.
[J]. ONCOLOGIST, 2022, 27 (10): : E815 - E818
[5] Transcriptomic profiling and genomic rearrangement landscape of Nigerian prostate cancer
Mavura, Yusuph
Song, Hanbing
Xie, Jamie
Tamayo, Pablo
Mohammed, Abdullahi
Lawal, Ahmad T.
Bello, Ahmad
Ibrahim, Sani
Faruk, Mohammed
Huang, Franklin W.
[J]. PROSTATE, 2023, 83 (05): : 395 - 402
[6] GENOMIC LANDSCAPE OF METASTATIC HORMONE- NAIVE PROSTATE CANCER
Mizuno, Kei
Akamatsu, Shusuke
Sumiyoshi, Takayuki
Goto, Takayuki
Kobayashi, Takashi
Yamasaki, Toshinari
Inoue, Takahiro
Fujimoto, Akihiro
Ogawa, Osamu
[J]. JOURNAL OF UROLOGY, 2020, 203 : E222 - E222
[7] Genomic landscape of metastatic hormone-naive prostate cancer
Mizuno, Kei
Akamatsu, Shusuke
Goto, Takayuki
Kobayashi, Takashi
Ogawa, Osamu
[J]. CANCER SCIENCE, 2021, 112 : 656 - 656
[8] THE GENOMIC LANDSCAPE OF BRCA2-MUTANT PROSTATE CANCER
Taylor, Renea
Thorne, Heather
Lawrence, Mitchell G.
Fraser, Michael
Livingstone, Julie
Espiritu, Shadrieele Melijah G.
Sliwinski, Ania
Murphy, Declan G.
Frydenberg, Mark
Bolton, Damien
Clouston, David
Boutros, Paul C.
Bristow, Robert G.
Risbridger, Gail P.
[J]. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2017, 13 : 32 - 32
[9] Traversing the genomic landscape of prostate cancer from diagnosis to death
Hieronymus, Haley
Sawyers, Charles L.
[J]. NATURE GENETICS, 2012, 44 (06) : 613 - 614
[10] THE DIVERSE GENOMIC LANDSCAPE OF LOW-RISK PROSTATE CANCER
Cooperberg, Matthew R.
Erho, Nicholas
Chan, June M.
Feng, Felix Y.
Cowan, Janet E.
Ong, Kaye
Alshalalfa, Mohammed
Kolisnik, Tyler
Margrave, Jennifer
Aranes, Maria
du Plessis, Marguerite
Buerki, Christine
Zhao, Shuang G.
Tenggara, Imelda
Davicioni, Elai
Carroll, Peter R.
[J]. JOURNAL OF UROLOGY, 2017, 197 (04): : E912 - E912

← 1 2 3 4 5 →