Statistical Analysis of Results from the Attestation of Biological Standard Samples: Use of the Mann-Whitney Test

被引:2
|
作者
Fadeikina, O., V [1 ]
Volkova, R. A. [1 ]
Karpova, E., V [1 ]
机构
[1] Minist Hlth Russian Federat, Sci Ctr Expert Evaluat Med Prod, Bldg 2,8 Petrovskii Blvd, Moscow 127051, Russia
关键词
biological standard samples; attestation; nonparametric test; Mann-Whitney test; Z statistic; assessment of uniformity of two independent datasets;
D O I
10.1007/s11094-019-02057-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
An algorithm for assessing the possibility of joining two datasets obtained by different operators for attestation of standard samples of biological medicinal substances (SS BMS) is proposed. These studies tested the uniformity of the results obtained by different operators during attestation of industrial standard samples of the specific activity of an oral poliomyelitis vaccine, i.e., divalent live attenuated types 1 and 3 "BiVak polio" vaccine, using the Mann-Whitney and Z statistics for independent sets run manually using a formula, with subsequent interpretation of the results. Results from calculation of the Mann-Whitney test in Statistica software (version 10) are presented.
引用
收藏
页码:655 / 659
页数:5
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