β-fibrinogen gene-455 G/A polymorphism in Korean ischemic stroke patients

被引:9
|
作者
Lee, Seung-Han [1 ]
Kim, Myeong-Kyu [1 ]
Park, Man-Seok [1 ]
Choi, Seong-Nen [1 ]
Kim, Joon-Tae [1 ]
Kim, Byeong-Chae [1 ]
Cho, Ki-Hyun [1 ]
机构
[1] Chonnam Natl Univ, Sch Med, Dept Neurol, Kwangju 501757, South Korea
来源
JOURNAL OF CLINICAL NEUROLOGY | 2008年 / 4卷 / 01期
关键词
fibrinogen; polymorphism; stroke;
D O I
10.3988/jcn.2008.4.1.17
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose: We investigated the relationship between the beta-fibrinogen gene (FGB) -455 G/A polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke: large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO). Methods: A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with restrictive enzyme Hae III and automatic DNA sequencing. Results: The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level (p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455 G/A polymorphism did not differ between LAA and SVO. Conclusions: The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardicembolic stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A polymorphism.
引用
收藏
页码:17 / 22
页数:6
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