Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal

被引:218
|
作者
Hanson, Nicola D. [1 ]
Owens, Michael J. [1 ]
Nemeroff, Charles B. [2 ]
机构
[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA
[2] Univ Miami, Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA
基金
美国医疗保健研究与质量局;
关键词
neurogenesis; dentate gyrus; neurotrophic factors; stress; depression; antidepressant; ADULT HIPPOCAMPAL NEUROGENESIS; RAT DENTATE GYRUS; NEUROTROPHIC FACTOR BDNF; INCREASES CELL-PROLIFERATION; CHRONIC PSYCHOSOCIAL STRESS; REPEATED RESTRAINT STRESS; NEWLY GENERATED NEURONS; SYNAPTIC PLASTICITY; PROGENITOR CELLS; GRANULE CELLS;
D O I
10.1038/npp.2011.220
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular zone of the dentate gyrus is regulated negatively by stressful experiences and positively by treatment with antidepressant drugs and (2) that alterations in the rate of neurogenesis play a fundamental role in the pathology and treatment of major depression. This hypothesis is supported by important experimental observations, but is challenged by equally compelling contradictory reports. This review summarizes the phenomenon of adult hippocampal neurogenesis, the initial and continued evidence leading to the development of the neurogenesis hypothesis of depression, and the recent studies that have disputed and/or qualified those findings, to conclude that it can be affected by stress and antidepressants under certain conditions, but that these effects do not appear in all cases of psychological stress, depression, and antidepressant treatment. Neuropsychopharmacology (2011) 36, 2589-2602; doi:10.1038/npp.2011.220; published online 21 September 2011
引用
收藏
页码:2589 / 2602
页数:14
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