ADAM and Eph: How ephrin-signaling cells become detached

被引：16

作者：

Mancia, F ^{[1
]}

Shapiro, L

机构：

[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[2] Columbia Univ, Edward S Harkness Eye Inst, New York, NY 10032 USA

来源：

CELL | 2005年 / 123卷 / 02期

关键词：

D O I：

10.1016/j.cell.2005.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.

引用

页码：185 / 187

页数：3

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