Tetrazole based amides as growth hormone secretagogues

被引：12
|
作者：
Li, James J. [1 ]
Wang, Haixia [1 ]
Li, Jun [1 ]
Qu, Fucheng [1 ]
Swartz, Stephen G. [1 ]
Hernandez, Andres S. [1 ]
Biller, Scott A. [1 ]
Robl, Jeffrey A. [1 ]
Tino, Joseph A.
Slusarchyk, Dorothy
Seethala, Ramakrishna
Sleph, Paul
Yan, Mujing
Grover, Gary
Flynn, Neil
Murphy, Brian J.
Gordon, David
机构：
[1] Bristol Myers Squibb Res & Dev, Princeton, NJ 08543 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 08期
关键词：
GHS; growth hormone secretagogues; Tetrazole amide;
D O I：
10.1016/j.bmcl.2008.03.059
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2536 / 2539
页数：4
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