Synthesis of P-chiral, phosphorothioic acid analogs of N-phospholeucinamide

被引：8
|
作者：
Thompson, CM [1 ]
Lin, J [1 ]
机构：
[1] LOYOLA UNIV,DEPT CHEM,CHICAGO,IL 60626
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期
关键词：
N-phospholeucinamide; phosphoramidothioic acid; stereoisomer;
D O I：
10.1016/S0040-4039(96)02107-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diastereomeric mixture of R(p)- and S-p- N-[O-methyl phosphorothioic acid]leucinamides were synthesized by thiophosphorlation of leucinamide followed by monodealkylation of the phosphate methyl ester. Individual diastereomers were prepared by a sequence utilizing selective protection of the thioic acid moiety as the S-benzyl group, chromatographic separation, and deprotection. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：8979 / 8982
页数：4
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