A Phase 2 Study of the Safety and Efficacy of INCB050465, a Selective PI3Kδ Inhibitor, in Combination with Ruxolitinib in Patients with Myelofibrosis

被引:4
|
作者
Daver, Naval G. [1 ]
Kremyanskaya, Marina [2 ]
O'Connell, Casey [3 ]
Dao, Kim-Hien [4 ]
Oh, Stephen T. [5 ]
Gerds, Aaron T. [6 ]
Verstovsek, Srdan [1 ]
Erickson-Viitanen, Sue [7 ]
Zhou, Feng [7 ]
Assad, Albert [7 ]
Yacoub, Abdulraheem [8 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] Mt Sinai Hlth Syst, New York, NY USA
[3] Univ Southern Calif, Los Angeles, CA USA
[4] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
[5] Washington Univ, Sch Med, St Louis, MO USA
[6] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA
[7] Incyte Corp, Wilmington, DE USA
[8] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA
关键词
D O I
10.1182/blood-2018-99-111338
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
353
引用
收藏
页数:3
相关论文
共 50 条
  • [1] A Phase 2 Study of the Safety and Efficacy of INCB050465 in Combination with Ruxolitinib in Patients with Myelofibrosis (MF)
    Daver, Naval
    Dao, Kim-Hien
    Assad, Albert
    Verstovsek, Srdan
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 : S351 - S351
  • [2] Addition of parsaclisib (INCB050465), a PI3Kδ inhibitor, in patients with suboptimal response to ruxolitinib: a phase 2 study in patients with myelofibrosis
    Yacoub, Abdulraheem
    Wang, Eunice
    Rampal, Raajit
    Borate, Uma
    Kremyanskaya, Marina
    Ali, Haris
    Hobbs, Gabriela
    O'Connell, Casey
    Assad, Albert
    Erickson-Viitanen, Sue
    Zhou, Feng
    Burn, Timothy
    Daver, Naval
    BRITISH JOURNAL OF HAEMATOLOGY, 2021, 193 : 9 - 9
  • [3] Addition of parsaclisib (INCB050465), a PI3Kδ inhibitor, in patients with suboptimal response to ruxolitinib: A phase 2 study in patients with myelofibrosis.
    Yacoub, Abdulraheem
    Wang, Eunice S.
    Rampal, Raajit K.
    Borate, Uma
    Kremyanskaya, Marina
    Ali, Haris
    Hobbs, Gabriela S.
    O'Connell, Casey
    Assad, Albert
    Erickson-Viitanen, Sue
    Zhou, Feng
    Burn, Timothy C.
    Daver, Naval G.
    CANCER RESEARCH, 2021, 81 (13)
  • [4] Preclinical studies on potential therapeutic combination partners for the potent and selective PI3Kδ inhibitor INCB050465 in DLBCL
    Stubbs, Matthew C.
    Collins, Robert
    Hall, Leslie
    Volgina, Alla
    Koblish, Holly
    Lee, Sang Hyun
    Burn, Timothy
    Liu, Phillip C.
    Lu, Jin
    Yue, Eddy
    Li, Yun-Long
    Combs, Andrew P.
    Yao, Wenqing
    Hollis, Gregory
    Huber, Reid
    Ruggeri, Bruce
    Scherle, Peggy
    CANCER RESEARCH, 2017, 77
  • [5] Subgroup Analysis from a Phase 2 Study of the Efficacy and Safety of Parsaclisib, a Selective PI3Kδ Inhibitor, in Combination with Ruxolitinib in Patients with Myelofibrosis (MF)
    Yacoub, Abdulraheem
    Borate, Uma
    Rampal, Raajit
    Ali, Haris
    Wang, Eunice S.
    Gerds, Aaron T.
    Hobbs, Gabriela
    Kremyanskaya, Marina
    Winton, Elliott
    O'Connell, Casey
    Goel, Swati
    Oh, Stephen
    Schiller, Gary J.
    Assad, Albert
    Erickson-Viitanen, Sue
    Zhou, Feng
    Daver, Naval
    BLOOD, 2021, 138
  • [6] An Ongoing Open-Label Phase 1/2 Study of INCB050465, a Selective PI3Kδ Inhibitor, in Patients with Previously Treated B-Cell Malignancies
    Phillips, Tycel
    Ramchandren, Rod
    Wertheim, Michael S.
    Gutierrez, Martin E.
    Edenfield, William J.
    Dawkins, Fitzroy
    DeMarini, Doug J.
    Zhou, Li
    Yeleswaram, Swamy
    Newton, Robert C.
    Chen, Xuejun
    Forero-Torres, Andres
    BLOOD, 2016, 128 (22)
  • [7] Results From a Phase 1/2 Study of INCB050465, a Potent and Highly Selective PI3K delta Inhibitor, in Patients With Relapsed or Refractory B-Cell Malignancies
    Martin, Peter
    CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2018, 16 (04) : 9 - 10
  • [8] INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ)
    Yue, Eddy W.
    Li, Yun-Long
    Douty, Brent
    He, Chunhong
    Mei, Song
    Wayland, Brian
    Maduskuie, Thomas
    Falahatpisheh, Nikoo
    Sparks, Richard B.
    Polam, Padmaja
    Zhu, Wenyu
    Glenn, Joseph
    Feng, Hao
    Zhang, Ke
    Li, Yanlong
    He, Xin
    Katiyar, Kamna
    Covington, Maryanne
    Feldman, Patricia
    Shin, Niu
    Wang, Kathy He
    Diamond, Sharon
    Li, Yu
    Koblish, Holly K.
    Hall, Leslie
    Scherle, Peggy
    Yeleswaram, Swamy
    Xue, Chu-Biao
    Metcalf, Brian
    Combs, Andrew P.
    Yao, Wenqing
    ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (11): : 1554 - +
  • [9] Results from a Phase 1/2 Study of INCB050465, a Highly Selective and Highly Potent PI3Kδ Inhibitor, in Patients with Relapsed or Refractory B-Cell Malignancies (CITADEL-101)
    Forero-Torres, Andres
    Ramchandren, Rod
    Yacoub, Abdulraheem
    Wertheim, Michael S.
    Edenfield, William J.
    Caimi, Paolo
    Gutierrez, Martin
    Akard, Luke
    Escobar, Carolina
    Call, Justin
    Persky, Daniel
    Iyer, Swami P.
    DeMarini, Douglas J.
    Zhou, Li
    Yeleswaram, Swamy
    Phillips, Tycel J.
    BLOOD, 2017, 130
  • [10] INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL
    Shin, Niu
    Koblish, Holly
    Covington, Maryanne
    Li, Yanlong
    Wang, Kathy
    Wang, Qian
    Feldman, Patricia
    Hall, Leslie
    O'Connor, Sybil
    He, Xin
    Katiyar, Kamna
    Li, Yu
    Yue, Eddy W.
    Maduskuie, Thomas P.
    Douty, Brent
    Mei, Song
    Li, Yun-Long
    Xue, Chu-Biao
    Combs, Andrew
    Yao, Wenqing
    Diamond-Fosbenner, Sharon
    Yeleswaram, Swamy
    Newton, Robert
    Vaddi, Kris
    Huber, Reid
    Scherle, Peggy
    CANCER RESEARCH, 2015, 75