Convenient synthesis of (4R,5R)-4,5-bis(aminomethy1)2-isopropyl-1,3-dioxolane

被引：0
|
作者：
Jiang, Jian [1 ]
Wang, De Cai [1 ]
Lin, Wei [1 ]
Ouyang, Ping Kai [1 ]
机构：
[1] Nanjing Inst Chem Technol, Coll Life Sci & Pharmaceut Engn, Nanjing 210009, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 07期
基金：
中国国家自然科学基金;
关键词：
heptaplatin; aminomethyl; intermediate; anticancer drug;
D O I：
10.1016/j.cclet.2007.05.035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient approach for the preparation of (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl- 1,3-dioxolane is described. The target compound via two steps is synthesized from diethyl-2,3-0-isobutylidene-D-tartrate, through ammonolysis and reduction. (C) 2007 De Cai Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：783 / 784
页数：2
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