The gut microbiome and microbial translocation in multiple sclerosis

被引：47

作者：

Mirza, Ali ^{[1
,2
]}

Mao-Draayer, Yang ^{[3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Neurol, 4258 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Neurol, 4015 Alfred Taubman Biomed Sci Res Bldg, Ann Arbor, MI 48109 USA

来源：

CLINICAL IMMUNOLOGY | 2017年 / 183卷

关键词：

Multiple sclerosis; Microbiome; CNS; Gut-brain axis; Microbial translocation; Intestinal permeability; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PATTERN-RECOGNITION RECEPTORS; INTESTINAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; FAECALIBACTERIUM-PRAUSNITZII; FECAL MICROBIOTA;

D O I：

10.1016/j.clim.2017.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：213 / 224

页数：12

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