Nardosinane Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava

被引：31

作者：

Lu, Yi ^{[1
]}

Li, Po-Ju ^{[1
]}

Hung, Wen-Yu ^{[1
]}

Su, Jui-Hsin ^{[2
]}

Wen, Zhi-Hong ^{[1
]}

Hsu, Chi-Hsin ^{[1
]}

Dai, Chang-Feng ^{[3
]}

Chiang, Michael Y. ^{[4
]}

Sheu, Jyh-Horng ^{[1
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Taiwan Coral Res Ctr, Checheng 944, Pingtung, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 02期

关键词：

PARALEMNALIA-THYRSOIDES; NORSESQUITERPENOIDS; CERVICORNI; AFRICANA; STEROIDS; FULVUM;

D O I：

10.1021/np100541a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 Were shown to possess significant neuroprotective activity.

引用

页码：169 / 174

页数：6

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