Scalable synthesis of dihydroxyterphenylphosphine ligands

被引：7

作者：

Yamaguchi, Miyuki ^{[1
]}

Suzuki, Kohei ^{[1
]}

Manabe, Kei ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan

来源：

TETRAHEDRON | 2015年 / 71卷 / 18期

基金：

日本学术振兴会;

关键词：

Phosphines; Ligands; Palladium; Cross-coupling; Site-selective; CROSS-COUPLING REACTIONS; OLIGOARENE-TYPE PHOSPHINES; ONE-POT SYNTHESIS; HALOGENATED NITROGEN; CATALYST; STRATEGY; HYDROFORMYLATION; IMINES; OXYGEN; ACID;

D O I：

10.1016/j.tet.2015.03.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed an improved method for the synthesis of dihydroxyterphenylphosphines (DHTPs), which are important ligands used in the palladium-catalyzed ortho-selective cross-coupling of dihalophenols or dihaloanilines. This method is simple, easily scalable, and has been used to produce multigram quantities of Cy-DHTP center dot HBF4 and Ph-DHTP in five steps. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2743 / 2747

页数：5

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