Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats

被引：40
|
作者：
Sangameswaran, B. [1 ]
Jayakar, B. [1 ]
机构：
[1] Vinayaka Missions Univ, Vinayaka Missions Coll Pharm, Salem 636008, India
来源：
JOURNAL OF NATURAL MEDICINES | 2008年 / 62卷 / 01期
关键词：
Amaranthus spinosus; anti-hyperglycemic; anti-hyperlipidemic; glibenclamide; spermatogenic;
D O I：
10.1007/s11418-007-0189-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Anti-diabetic, anti-hyperlipidemic and spermatogenic effects were studies with methanolic extract of stem of Amaranthus spinosus Linn (Family: Amaranthaceae) in diabetic rats. In streptozotocin (STZ)-induced diabetic rats, it was observed that both the standard drug (Glibenclamide) and methanolic extract of Amaranthus spinosus Linn. significantly exhibited control of blood glucose level on a 15day model. Further, the methanolic extract also showed significant anti-hyperlipidemic and spermatogenic effects in STZ-induced diabetic rats. The methanolic extract has also accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights. The present investigation of the plant established some pharmacological evidence to support the folklore claim that it is used as an anti-diabetic.
引用
收藏
页码：79 / 82
页数：4
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