N-(2-Chloropyrimidin-4-yl)-N,2-dimethyl-2H-indazol-6-amine

被引:3
|
作者
Qi, Hao-Fei [2 ]
Liu, Bing-Ni [1 ]
Liu, Mo [1 ]
Liu, Deng-Ke [1 ]
机构
[1] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China
[2] Tianjin Polytech Univ, Tianjin 300160, Peoples R China
关键词
TYROSINE KINASE INHIBITOR; PAZOPANIB;
D O I
10.1107/S1600536810042753
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title compound, C(13)H(12)ClN(5), which is a derivative of the antitumor agent pazopanib {systematic name: 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]-amino]-2-methylbenzolsulfonamide}, the indazole and pyrimidine fragments form a dihedral angle of 62.63 (5)degrees. In the crystal, pairs of molecules related by twofold rotational symmetry are linked into dimers through pi-pi interactions between the indazole ring systems [centroid-centroid distance = 3.720 (2) angstrom]. Weak intermolecular C-H center dot center dot center dot N hydrogen bonds further assemble these dimers into columns propagated in [001].
引用
收藏
页码:O2955 / U1397
页数:8
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