Identification of a novel DRB1 allele, DRB1*1112, by sequence-based DRB typing

被引：4
|
作者：
Luo, M
Blanchard, J
Maclean, I
Brunham, R
机构：
[1] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada
[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada
来源：
TISSUE ANTIGENS | 2001年 / 57卷 / 01期
关键词：
HLA-DRB1; allele; DRB1*1112;
D O I：
10.1034/j.1399-0039.2001.057001085.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We report here a novel DRB1 allele (DRB1*1112) identified during sequence-based HLA-DRB typing. Polymerase chain reaction with generic DRB primers and group-specific primers and subsequent sequencing yielded identical results. Molecular cloning and sequencing confirmed that the new DRB1 allele is identical to DRB1*11011 and 1129 at exon 2 except for a single nucleotide substitution at codon 37, changing the codon from Tyr (DRB1*11011) or Ser (DRB1*1129) to Phe.
引用
收藏
页码：85 / 86
页数：2
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