Molecular structure and affinity to 5-HT1A receptor of chlorophenyl(piperazinylalkyl)phthalimides

被引：0
|
作者：
Chumakov, YM [1 ]
Simonov, YA
Soboleva, SG
Sava, VM
Andronati, SA
Gdaniec, M
Bocelli, G
机构：
[1] Moldavian Acad Sci, Inst Appl Phys, Kishinev 2028, Moldova
[2] Ukrainian Acad Sci, AV Bogatsky Physicochem Inst, Odessa, Ukraine
[3] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland
[4] CNR, Ctr Studio Strutturist Diffrattometr, I-43100 Parma, Italy
来源：
SUPRAMOLECULAR CHEMISTRY | 2000年 / 12卷 / 02期
关键词：
psychotropic agents; chlorophenyl(piperazinylalkyl)phtalimides; serotonin receptors; affinity; pharmacophore;
D O I：
10.1080/10610270008027456
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
X-ray crystallography, quantum-chemical calculations and conformational analysis have been employed to study chlorophenyl(piperazinylalkyl)phthalimides, potential ligands of 5-HT1A receptor. The molecular recognition of investigated compounds by 5-HT(1A)serotonin receptor has been estimated according to their ability to inhibit the [(3)H8]-DPAT binding. The model for 5-HT1A pharmacophore has been proposed based on crystal structures of N-(aryl)piperazinyl - alkylphthalimides.
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页码：225 / 227
页数：3
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