Tastant perception signals are formed by the specific interactions between bitter tastant molecules and corresponding taste receptors. The signals are amplified and transmitted through a series of pathways, and reaches the gustatory cortex within the brain. Finally taste sensation takes shape. Cell-based sensor, using living cells as the recognition elements to detect agents functionally with physiological changes to cells, have been rapidly developed in recent years. CSPE is fixed in a flow-cell, a methacrylate wall-jet flow-cell for flow-injection analysis, with an open/close controlling system and a convenient sensor replacement function. It has an O-ring which limits the electrochemical cell's volume. However, the physiologic relevance of quinine receptor gene expression is more complex, and has not yet been confirmed. These factors lead to less SNR eigen peak distance regularity in N-Phenylthiourea detection than in quinine detection, even if the IMITD cell-based sensor is modulated by the same parameter group.
