Precise chromosomal locations of the genes for dentatorubral-pallidoluysian atrophy (DRPLA), von Willebrand factor (F8vWF) and parathyroid hormone-like hormone (PTHLH) in human chromosome 12p by deletion mapping

被引：0

作者：

Kuwano, A

Morimoto, Y

Nagai, T

Fukushima, Y

Ohashi, H

Hasegawa, T

Kondo, I

机构：

[1] TOKYO METROPOLITAN KIYOSE CHILDRENS HOSP,DEPT PEDIAT,TOKYO,JAPAN

[2] SAITAMA CHILDRENS CTR,DEPT GENET,SAITAMA,JAPAN

[3] SHIZUOKA CHILDRENS HOSP,DEPT GENET,SHIZUOKA,JAPAN

来源：

HUMAN GENETICS | 1996年 / 97卷 / 01期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The precise chromosomal localization of the gene for dentatorubral-pallidoluysian atrophy (DRPLA) was detected by deletion mapping. Segregation patterns of genotypes of polymerase chain reaction products of DRPLA, von Willebrand factor (F8vWF), antigen CD4(p55) (CD4) and parathyroid hormone-like hormone (PTHLH) loci were studied in patients with del(12)(p13.3p13.3), del(12>(p12.3-p11.2), del(12)(p12.1-p11.2), del(12) (p11.2p11.2) and their parents. The gene for DRPLA was assigned to p13.1-p12.3 of chromosome 12. In addition, genes for F8vWF and PTHLH were mapped to p13.2 and p11.2 of chromosome 12, respectively.

引用

页码：95 / 98

页数：4