Oncogenic Viruses and Hepatocellular Carcinoma

被引：20
|
作者：
Ben Ari, Ziv [1 ,2 ,3 ]
Weitzman, Ella [1 ,3 ]
Safran, Michel [1 ,2 ]
机构：
[1] Chaim Sheba Med Ctr, Liver Dis Ctr, IL-52621 Ramat Gan, Israel
[2] Chaim Sheba Med Ctr, Liver Res Lab, IL-52621 Ramat Gan, Israel
[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
来源：
CLINICS IN LIVER DISEASE | 2015年 / 19卷 / 02期
关键词：
Hepatocellular carcinoma; Oncogenic viruses; Hepatitis B; Hepatitis C; HEPATITIS-C-VIRUS; SUSTAINED VIROLOGICAL RESPONSE; NONSTRUCTURAL PROTEIN NS3; E-CADHERIN EXPRESSION; X-PROTEIN; LONG-TERM; CORE PROTEIN; ANTIVIRAL THERAPY; NONCIRRHOTIC PATIENTS; INTERFERON THERAPY;
D O I：
10.1016/j.cld.2015.01.006
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
About 80% of hepatocellular carcinoma (HOC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HOC prevention a major goal of antiviral therapy. HOC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in promoting HOC development are still either directly or indirectly are still speculative, but the evidence for both effects is compelling. In patients with chronic hepatitis viral infection, cirrhosis is not a prerequisite for tumorigenesis.
引用
收藏
页码：341 / +
页数：21
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