The large Rep protein of adeno-associated virus type 2 is polyubiquitinated

被引：3

作者：

Sukhu, Loretta ^{[1
]}

Pintel, David ^{[1
]}

机构：

[1] Univ Missouri, Bond Life Sci Ctr, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2011年 / 92卷

关键词：

UBIQUITIN-PROTEASOME PATHWAY; CAPSID PROTEINS;

D O I：

10.1099/vir.0.034975-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five adenovirus (Ad) gene products are required for efficient replication of co-infecting adeno-associated virus (AAV); however, the combined net enhancement by these factors is composed of both positive and negative effects. Similar to previous results with AAV Rep52, AAV2 large Rep was targeted for ubiquitination and degradation by the Ad E4orf6/E1b 55 kDa, cullin 5-containing, E3-ubiquitin ligase. Additionally, large Rep was targeted for ubiquitination via extension of ubiquitin lysine K48 and K63 both in the presence and absence of E4orf6.

引用

页码：2792 / 2796

页数：5

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