The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F (APOBEC3F [A3F]) and A3G proteins are effective inhibitors of infection by various retroelements and share similar to 50% amino acid sequence identity. We therefore undertook comparative analyses of the protein and RNA compositions of A3F- and A3G-associated ribonucleoprotein complexes (RNPs). Like A3G, A3F is found associated with a complex array of cytoplasmic RNPs and can accumulate in RNA-rich cytoplasmic microdomains known as mRNA processing bodies or stress granules. While A3F RNPs display greater resistance to disruption by RNase digestion, the major protein difference is the absence of the Ro60 and La autoantigens. Consistent with this, A3F RNPs also lack a number of small polymerase III RNAs, including the RoRNP-associated Y RNAs, as well as 7SL RNA. Alu RNA is, however, present in A3F and A3G RNPs, and both proteins suppress Alu element retrotransposition. Thus, we define a number of subtle differences between the RNPs associated with A3F and A3G and speculate that these contribute to functional differences that have been described for these proteins.
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Inst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
Bouzidi, Mohamed S.
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Caval, Vincent
Suspene, Rodolphe
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Inst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
Suspene, Rodolphe
Hallez, Camille
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Inst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
Hallez, Camille
Pineau, Pascal
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Inst Pasteur, Nucl Org & Oncogenesis Unit, INSERM U579, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
Pineau, Pascal
Wain-Hobson, Simon
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Inst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
Wain-Hobson, Simon
Vartanian, Jean-Pierre
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Inst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, FranceInst Pasteur, Mol Retrovirol Unit, CNRS URA 3015, 28 Rue Dr Roux, F-75724 Paris 15, France
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Univ N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA
Argos Therapeut Inc, Durham, NC USAUniv N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA
Krisko, John F.
Begum, Nurjahan
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Univ N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USAUniv N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA
Begum, Nurjahan
Baker, Caroline E.
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Univ N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USAUniv N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA
Baker, Caroline E.
Foster, John L.
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Univ N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USAUniv N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA
Foster, John L.
Garcia, J. Victor
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Univ N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USAUniv N Carolina, Sch Med, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA