Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins

被引:68
|
作者
Gallois-Montbrun, Sarah [1 ]
Holmes, Rebecca K. [1 ]
Swanson, Chad M. [1 ]
Fernandez-Ocana, Mireia [2 ]
Byers, Helen L. [3 ]
Ward, Malcolm A. [3 ]
Malim, Michael H. [1 ]
机构
[1] Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England
[2] Kings Coll London, Inst Psychiat, MRC, Ctr Neurodegenerat Res, London SE5 8AF, England
[3] Kings Coll London, Inst Psychiat, Proteome Sci Plc, London SE5 8AF, England
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
D O I
10.1128/JVI.00287-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F (APOBEC3F [A3F]) and A3G proteins are effective inhibitors of infection by various retroelements and share similar to 50% amino acid sequence identity. We therefore undertook comparative analyses of the protein and RNA compositions of A3F- and A3G-associated ribonucleoprotein complexes (RNPs). Like A3G, A3F is found associated with a complex array of cytoplasmic RNPs and can accumulate in RNA-rich cytoplasmic microdomains known as mRNA processing bodies or stress granules. While A3F RNPs display greater resistance to disruption by RNase digestion, the major protein difference is the absence of the Ro60 and La autoantigens. Consistent with this, A3F RNPs also lack a number of small polymerase III RNAs, including the RoRNP-associated Y RNAs, as well as 7SL RNA. Alu RNA is, however, present in A3F and A3G RNPs, and both proteins suppress Alu element retrotransposition. Thus, we define a number of subtle differences between the RNPs associated with A3F and A3G and speculate that these contribute to functional differences that have been described for these proteins.
引用
收藏
页码:5636 / 5642
页数:7
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