A short procedure for synthesis of 4-ethynyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl nitroxide

被引:17
|
作者
Gannett, PM [1 ]
Darian, E [1 ]
Powell, JH [1 ]
Johnson, EM [1 ]
机构
[1] W Virginia Univ, Sch Pharm, Morgantown, WV 26506 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1081/SCC-100104464
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The spin-probe labeling technique has been applied to DNA and offers the possibility of studying antisense agents in cells. Simpler syntheses of spin-probes for incorporation into DNA would facilitate this. Here, we describe the synthesis of a new spin probe that requires half the number of steps of related 5 ring nitroxide.
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页码:2137 / 2141
页数:5
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