Effects and Mechanisms of Tacrolimus on Development of Murine Th17 Cells

被引：6
|
作者：
Zhang, X. -J. [1 ]
Kang, Y. -D. [1 ]
Xiao, L. [1 ]
Li, R. -D. [1 ]
Ding, G. -S. [1 ]
Wang, Z. -X. [1 ]
Fu, Z. -R. [1 ]
机构：
[1] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Organ Transplantat, Shanghai 200003, Peoples R China
来源：
TRANSPLANTATION PROCEEDINGS | 2010年 / 42卷 / 09期
关键词：
T-CELLS; ALLOGRAFT-REJECTION; DIFFERENTIATION; GENERATION; INJURY; IL-17; RESPONSES; PROMOTES; T(H)17; LONG;
D O I：
10.1016/j.transproceed.2010.08.033
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tacrolimus (Tac, FK506) is a widely used T-cell-targeted immunosuppression drug known as a calcineurin inhibitor. However, its pharmacologic effects on T-helper type 17 (Th17) cells have not been fully elucidated. Herein, we demonstrate that Tac inhibits Th17 cell differentiation and proliferation, and expression of IL-17 messenger RNA. The proposed mechanism is that Tac inhibits calcineurin and T-cell receptor stimulation-induced cell division. Because Th17 cells participate in allograft rejection, the results of the present study suggest a novel model of immunosuppression effects of Tac. In addition, they provide further implications for the therapeutic immunosuppression effects of Tac on allograft rejection.
引用
收藏
页码：3779 / 3783
页数：5
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