Preclinical evaluation of heat shock protein 90 inhibitor, IPI-504 in human pancreatic xenografts.

被引：0
|
作者：
Song, Dongweon
Jimeno, Antonio
Kulesza, Piotr
Messersmith, Wells
Zhang, Xian Feng
Bouraoud, Nadia
Pien, Christine
Tong, Jeffery
Hidalgo, Manuel
机构：
[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[2] Infin Pharmaceut Inc, Cambridge, MA USA
来源：
CANCER RESEARCH | 2006年 / 66卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5475
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer
    Song, Dongweon
    Chaerkady, Raghothama
    Tan, Aik Choon
    Garcia-Garcia, Elena
    Nalli, Anuradha
    Suarez-Gauthier, Ana
    Lopez-Rios, Fernando
    Zhang, Xian Feng
    Solomon, Anna
    Tong, Jeffrey
    Read, Margaret
    Fritz, Christian
    Jimeno, Antonio
    Pandey, Akhilesh
    Hidalgo, Manuel
    MOLECULAR CANCER THERAPEUTICS, 2008, 7 (10) : 3275 - 3284
  • [2] PRECLINICAL STUDY OF THE HSP-90 INHIBITOR IPI-504 IN MALIGNANT GLIOMA
    Bota, Daniela
    Keir, Stephen
    Albert, Kelsey
    Normant, Emmanuel
    Friedman, Henry
    NEURO-ONCOLOGY, 2008, 10 (05) : 791 - 791
  • [3] Efficacy of IPI-504 \#8220;a novel inhibitor of heat shock protein 90\#8221; in a preclinical mouse model of gastrointestinal stromal tumor (GIST)
    Floris, Giuseppe
    Debiec-Rychter, Maria
    Sciot, Raf
    Stefan, Cristiana
    Wozniak, Agnieszka
    Machiels, Kathleen
    Normant, Emmanuel
    Schoffski, Patrick
    CANCER RESEARCH, 2009, 69
  • [4] Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent
    Hanson, Britt Erika
    Vesole, David H.
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2009, 18 (09) : 1375 - 1383
  • [5] The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas
    Abramson, Jeremy S.
    Chen, Wen
    Juszczynski, Przemyslaw
    Takahashi, Hidenobu
    Neuberg, Donna
    Kutok, Jeffery L.
    Takeyama, Kunihiko
    Shipp, Margaret A.
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 144 (03) : 358 - 366
  • [6] The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo
    Douglas, Mark
    Lim, Alice R.
    Porter, James R.
    West, Kip
    Pink, Melissa M.
    Ge, Jie
    Wylie, Andrew A.
    Tibbits, Thomas T.
    Biggs, Kurtis
    Curtis, Michael
    Palombella, Vito J.
    Adams, Julian
    Fritz, Christian C.
    Normant, Emmanuel
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12) : 3369 - 3378
  • [7] Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non-Small-Cell Lung Cancer
    Sequist, Lecia V.
    Gettinger, Scott
    Senzer, Neil N.
    Martins, Renato G.
    Jaenne, Pasi A.
    Lilenbaum, Rogerio
    Gray, Jhanelle E.
    Iafrate, A. John
    Katayama, Ryohei
    Hafeez, Nafeeza
    Sweeney, Jennifer
    Walker, John R.
    Fritz, Christian
    Ross, Robert W.
    Grayzel, David
    Engelman, Jeffrey A.
    Borger, Darrell R.
    Paez, Guillermo
    Natale, Ronald
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (33) : 4953 - 4960
  • [8] Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer
    Oh, William K.
    Galsky, Matthew D.
    Stadler, Walter M.
    Srinivas, Sandy
    Chu, Franklin
    Bubley, Glenn
    Goddard, J.
    Dunbar, Joi
    Ross, Robert W.
    UROLOGY, 2011, 78 (03) : 626 - 630
  • [9] The Heat Shock Protein 90 Inhibitor IPI-504 Induces KIT Degradation, Tumor Shrinkage, and Cell Proliferation Arrest in Xenograft Models of Gastrointestinal Stromal Tumors
    Floris, Giuseppe
    Debiec-Rychter, Maria
    Wozniak, Agnieszka
    Stefan, Cristiana
    Normant, Emmanuel
    Faa, Gavino
    Machiels, Kathleen
    Vanleeuw, Ulla
    Sciot, Raf
    Schoeffski, Patrick
    MOLECULAR CANCER THERAPEUTICS, 2011, 10 (10) : 1897 - 1908
  • [10] IPI-504: A novel hsp90 inhibitor with in vitro and in vivo antitumor activity
    Mitsiades, CS
    Mitsiades, N
    Rooney, M
    Negri, J
    Geer, CC
    Pink, M
    Pien, C
    Hideshima, T
    Chauhan, D
    Munshi, NC
    Richardson, PG
    Barrett, J
    Tong, JK
    Grayzel, D
    Palombella, V
    Adams, J
    Anderson, KC
    BLOOD, 2004, 104 (11) : 660A - 660A
12345