Newcastle disease is highly pathogenic to poultry and many other avian species. However, the Newcastle disease virus (NDV) has also been reported from many non-avian species. The NDV fusion protein (F) is a major determinant of its pathogenicity and virulence. The functionalities of F gene have been explored for the development of vaccine and diagnostics against NDV. Although the F protein is well studied but the codon usage and its nucleotide composition from NDV isolated from different species have not yet been explored. In present study, we have analyzed the factors responsible for the determination of codon usage in NDV isolated from four major avian host species. The F gene of NDV is analyzed for its base composition and its correlation with the bias in codon usage. Our result showed that random mutational pressure is responsible for codon usage bias in F protein of NDV isolates. Aromaticity, GC3s, and aliphatic index were not found responsible for species based synonymous codon usage bias in F gene of NDV. Moreover, the low amount of codon usage bias and expression level was further confirmed by a low CAI value. The phylogenetic analysis of isolates was found in corroboration with the relatedness of species based on codon usage bias. The relationship between the host species and the NDV isolates from the host does not represent a significant correlation in our study. The present study provides a basic understanding of the mechanism involved in codon usage among species.
机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Meng Wang
Yong-sheng Liu
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Yong-sheng Liu
Jian-hua Zhou
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Jian-hua Zhou
Hao-tai Chen
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Hao-tai Chen
Li-na Ma
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Li-na Ma
Yao-zhong Ding
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Yao-zhong Ding
Wen-qian Liu
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Wen-qian Liu
Yuan-xing Gu
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
Yuan-xing Gu
Jie Zhang
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机构:Lanzhou Veterinary Research Institute,Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Wang, Meng
Liu, Yong-sheng
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Liu, Yong-sheng
Zhou, Jian-hua
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Zhou, Jian-hua
Chen, Hao-tai
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Chen, Hao-tai
Ma, Li-na
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Ma, Li-na
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Ding, Yao-zhong
Liu, Wen-qian
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
Liu, Wen-qian
Gu, Yuan-xing
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, State Key Lab Vet Etiol Biol,Minist Agr, Lanzhou 730046, Peoples R China
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R China
Zhou, Jian-Hua
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Zhang, Jie
Chen, Hao-Tai
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R China
Chen, Hao-Tai
Ma, Li-Na
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R China
Ma, Li-Na
Liu, Yong-Sheng
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Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R ChinaChinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr,Key Lab Anim Virol, Lanzhou 730046, Peoples R China
机构:
King Faisal Univ, Dept Biomed Sci, Coll Clin Pharm, POB 400, Al Hasa 31982, Saudi ArabiaKing Faisal Univ, Dept Biomed Sci, Coll Clin Pharm, POB 400, Al Hasa 31982, Saudi Arabia
Hussain, Snawar
Rasool, Sahibzada Tasleem
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King Faisal Univ, Dept Biomed Sci, Coll Clin Pharm, POB 400, Al Hasa 31982, Saudi ArabiaKing Faisal Univ, Dept Biomed Sci, Coll Clin Pharm, POB 400, Al Hasa 31982, Saudi Arabia