[99mTc-BBPA]: A possible SPECT agent to understand the role of 18-kDa translocator protein (PBR/TSPO) during neuro-glial interaction

被引：2

作者：

Kumari, Neelam ^{[1
,2
,3
]}

Kaul, Ankur ^{[2
]}

Deepika ^{[2
,4
]}

Srivastava, Krishna ^{[4
]}

Mishra, Gauri ^{[6
]}

Bhagat, Sunita ^{[3
]}

Singh, Vinay Kumar ^{[5
]}

KumarTiwari, Anjani ^{[1
,2
]}

机构：

[1] Babasaheb Bhimrao Ambedkar Cent Univ, Dept Chem, Sch Phys & Decis Sci SPDS, Lucknow 226025, Uttar Pradesh, India

[2] Def Res & Dev Org, Inst Nucl Med & Allied Sci, Div Cyclotron & Radiopharmaceut Sci, Brig SK Mazumdar Rd, Delhi 110054, India

[3] Univ Delhi, Dept Chem, New Delhi 110054, India

[4] SRMU, Fac Chem Sci, Dewa Rd, Lucknow 225003, Uttar Pradesh, India

[5] Dr SMNR Univ, Dept Chem, Lucknow 226018, Uttar Pradesh, India

[6] Univ Delhi, Swami Shraddhanand Coll, Dept Zool, Delhi 110036, India

来源：

BIOORGANIC CHEMISTRY | 2022年 / 121卷

关键词：

Glia; TSPO; SPECT; Tc-9(9m); Imaging; 18 KDA TSPO; BENZODIAZEPINE-RECEPTOR; DERIVATIVES; DESIGN; TUMORIGENICITY; VISUALIZATION; RADIOLIGANDS; CANCER; MODEL; VIVO;

D O I：

10.1016/j.bioorg.2022.105678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translocator protein (TSPO, 18 kDa) is one of the most promising biomarker to understand the role of neuroinflammation in human as well as in different animal species. Here we report a new TSPO-selective ligand 2-(5-(2-(bis(pyridin-2-yl methyl)amino)acetamido)-2-oxobenzo[d] oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide, BBPA, which is supposed to be a potential probe to understand the role of TSPO in neuro-glial interaction through SPECT modality.

引用

页数：5