Effect of serotonin on cytokine mRNA expression in rat hippocampal astrocytes

被引：37
|
作者：
Pousset, F
Fournier, J
Legoux, P
Keane, P
Shire, D
Soubrie, P
机构：
[1] SANOFI RECH, F-31036 TOULOUSE, FRANCE
[2] SANOFI RECH, LABEGE INNOPOLE, F-31676 LABEGE, FRANCE
[3] SANOFI RECH, F-34184 MONTPELLIER, FRANCE
来源：
MOLECULAR BRAIN RESEARCH | 1996年 / 38卷 / 01期
关键词：
serotonin; cytokine; semi-quantitative polymerase chain reaction;
D O I：
10.1016/0169-328X(95)00324-L
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Serotonin is a widely distributed neurotransmitter which elicits a range of central activities. We examined the effect of serotonin on cytokine mRNA expression by rat hippocampal astrocytes in primary cultures. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis shows that interleukin-6 (IL6) mRNA is expressed after 10(-12) M serotonin stimulation whereas transforming growth factor-beta (TGF beta) and tumor necrosis factor (TNF alpha) are induced by 10(-10) M serotonin. These inductions appeared after 1 h stimulation for IL6 and TNF alpha, whereas that of TGF beta appeared after 4 h. The present results provide the first evidence that serotonin can influence astrocyte cytokine production, and thus this neurotransmitter may be considered a potential neuroimmunomodulator.
引用
收藏
页码：54 / 62
页数：9
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