A Novel Fluorescent Probe for Hydrogen Peroxide and Its Application in Bio-Imaging

被引：16

作者：

Zuo, Yingying ^{[1
]}

Jiao, Yang ^{[1
]}

Ma, Chunming ^{[1
]}

Duan, Chunying ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 11期

基金：

中国国家自然科学基金;

关键词：

hydrogen peroxide; reactive oxygen species; fluorescence; imaging; OXYGEN SPECIES ROS; LIVING CELLS; H2O2; MITOCHONDRIA; VISCOSITY; PROGRESS;

D O I：

10.3390/molecules26113352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen peroxide (H2O2) plays an important role in the human body and monitoring its level is meaningful due to the relationship between its level and diseases. A fluorescent sensor (CMB) based on coumarin was designed and its ability for detecting hydrogen peroxide by fluorescence signals was also studied. The CMB showed an approximate 25-fold fluorescence enhancement after adding H2O2 due to the interaction between the CMB and H2O2 and had the potential for detecting physiological H2O2. It also showed good biocompatibility and permeability, allowing it to penetrate cell membranes and zebrafish tissues, thus it can perform fluorescence imaging of H2O2 in living cells and zebrafish. This probe is a promising tool for monitoring the level of H2O2 in related physiological and pathological research.

引用

页数：12

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