A concise diastereoselective synthesis of (2S,3S,4R)-3,4-dihydroxyglutamic acid

被引：11
|
作者：
Oba, M [1 ]
Koguchi, S [1 ]
Nishiyama, K [1 ]
机构：
[1] Tokai Univ, Dept Mat Sci & Technol, Numazu, Shizuoka 4100395, Japan
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 34期
关键词：
D O I：
10.1016/S0040-4039(01)01120-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise diastereoselective synthesis of (2S,3S,4R)-3,4-dihydroxyglutamic acid, one of eight possible stereoisomers of 3,4-dihydroxyglutamic acids, is described. The key reaction in this synthesis is stereoselective cyanation of an optically active N-acyliminium intermediate derived from L-tartaric acid with tributyltin cyanide. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5901 / 5902
页数：2
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