Role of Class II Nuclear Receptors in Liver Carcinogenesis

被引:8
|
作者
Li, Guodong [1 ,2 ]
Guo, Grace L. [1 ]
机构
[1] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA
[2] Harbin Med Univ, Canc Treatment Ctr, Dept Abdominal Surg, Affiliated Hosp 4, Harbin, Peoples R China
关键词
Class II nuclear receptors; constitutive androstane receptor; farnesoid X receptor; hepatocellular carcinoma; liver X receptors; pregnane X receptor; peroxisome proliferator-activated receptors; retinoic acid receptors; PROLIFERATOR-ACTIVATED RECEPTORS; RETINOIC-ACID-RECEPTOR; CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR; PREGNANE-X-RECEPTOR; UNION-OF-PHARMACOLOGY; BETA/DELTA PPAR-BETA/DELTA; GLOBAL CANCER STATISTICS; E-2 SIGNALING PATHWAYS; CELL-CYCLE ARREST; HEPATOCELLULAR-CARCINOMA;
D O I
10.2174/187152011796011064
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad range of pathophysiological functions in the liver, including cholesterol and bile acid homeostasis; lipid and glucose metabolism; inflammation; liver regeneration and hepatocellular carcinogenesis. Due to highly complicated molecular mechanisms in the development and progression of hepatocellular carcinoma (HCC), HCC is still one of the most common malignancies in the world. Given the pivotal functions of the Class II NRs in the liver, the roles of these NRs in hepatocellular carcinogenesis are emerging. This review summarizes the roles of Class II NRs in liver carcinogenesis and their potential application in the prevention and treatment of HCC.
引用
收藏
页码:529 / 542
页数:14
相关论文
共 50 条
  • [1] NUCLEAR RECEPTORS AND CHEMICAL CARCINOGENESIS
    GREEN, S
    TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (06) : 251 - 255
  • [2] Pathogenesis of alcoholic liver disease: the role of nuclear receptors
    Gyamfi, Maxwell Afari
    Wan, Yu-Jui Yvonne
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (05) : 547 - 560
  • [3] Role of the class II tumor suppressor gene maspin in thyroid carcinogenesis
    Boltze, C
    Hoang-Vu, C
    Schneider-Stock, R
    Lehnert, H
    Roessner, A
    VERHANDLUNGEN DER DEUTSCHEN GESELLSCHAFT FUR PATHOLOGIE, 88. TAGUNG: ANDROPATHOLOGIE TRANSPLANTATIONSPATHOLOGIE, 2004, 88 : 237 - 245
  • [4] The role of receptors in multistage carcinogenesis
    Pitot, HC
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1995, 333 (1-2) : 3 - 14
  • [5] Hepatitis C-associated liver carcinogenesis:Role of PML nuclear bodies
    Kerstin Herzer
    Guido Gerken
    Thomas G Hofmann
    World Journal of Gastroenterology, 2014, (35) : 12367 - 12371
  • [6] Hepatitis C-associated liver carcinogenesis: Role of PML nuclear bodies
    Herzer, Kerstin
    Gerken, Guido
    Hofmann, Thomas G.
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (35) : 12367 - 12371
  • [7] Type II nuclear receptors with potential role in Alzheimer disease
    Jonathan, Munoz-Cabrera
    Adrian, Sandoval-Hernandez
    Gonzalo, Arboleda
    MOLECULAR ASPECTS OF MEDICINE, 2021, 78
  • [8] Role of Alcohol in Liver Carcinogenesis
    McKillop, Iain H.
    Schrum, Laura W.
    SEMINARS IN LIVER DISEASE, 2009, 29 (02) : 222 - 232
  • [9] Role of retinoic receptors in lung carcinogenesis
    Bogos, Krisztina
    Renyi-Vamos, Ferenc
    Kovacs, Gabor
    Tovari, Jozsef
    Dome, Balazs
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2008, 27 (1)
  • [10] THE ROLE OF HORMONES IN LIVER CARCINOGENESIS
    GRIFFIN, AC
    RICHARDSON, HL
    ROBERTSON, CH
    ONEAL, MA
    SPAIN, JD
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1955, 15 (05) : 1623 - 1632