Class II nuclear receptors;
constitutive androstane receptor;
farnesoid X receptor;
hepatocellular carcinoma;
liver X receptors;
pregnane X receptor;
peroxisome proliferator-activated receptors;
retinoic acid receptors;
PROLIFERATOR-ACTIVATED RECEPTORS;
RETINOIC-ACID-RECEPTOR;
CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR;
PREGNANE-X-RECEPTOR;
UNION-OF-PHARMACOLOGY;
BETA/DELTA PPAR-BETA/DELTA;
GLOBAL CANCER STATISTICS;
E-2 SIGNALING PATHWAYS;
CELL-CYCLE ARREST;
HEPATOCELLULAR-CARCINOMA;
D O I:
10.2174/187152011796011064
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad range of pathophysiological functions in the liver, including cholesterol and bile acid homeostasis; lipid and glucose metabolism; inflammation; liver regeneration and hepatocellular carcinogenesis. Due to highly complicated molecular mechanisms in the development and progression of hepatocellular carcinoma (HCC), HCC is still one of the most common malignancies in the world. Given the pivotal functions of the Class II NRs in the liver, the roles of these NRs in hepatocellular carcinogenesis are emerging. This review summarizes the roles of Class II NRs in liver carcinogenesis and their potential application in the prevention and treatment of HCC.
机构:S. Green is Molecular Biology Group Leader, Imperial Chemical Industries PLC, Central Toxicology Laboratory, Macclesfield, Cheshire SK10 4TJ, Alderley Park
机构:
Department for Gastroenterology and Hepatology,University Hospital Essen
Department of General-,Visceral- und Transplantation Surgery,University Hospital EssenDepartment for Gastroenterology and Hepatology,University Hospital Essen
Kerstin Herzer
Guido Gerken
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机构:
Department for Gastroenterology and Hepatology,University Hospital EssenDepartment for Gastroenterology and Hepatology,University Hospital Essen
Guido Gerken
Thomas G Hofmann
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h-index: 0
机构:
Cellular Senescence Group,DKFZ-ZMBH Alliance,Deutsches Krebsforschungszentrum (dkfz.)Department for Gastroenterology and Hepatology,University Hospital Essen