Design and synthesis of novel multivalent mannosides targeting the mannose receptor

被引：7
|
作者：
Yin, Zhao-Jun [1 ]
Li, Qing [1 ]
Meng, Xiang-Bao [1 ]
Li, Zhong-Jun [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci,State Key Lab Nat & Biomimet D, Beijing 100083, Peoples R China
来源：
CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 18期
基金：
中国国家自然科学基金;
关键词：
multivalent; mannoside; mannose receptor;
D O I：
10.1016/j.carres.2007.08.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2729 / 2734
页数：6
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