Relationship between the UPLC-Q-TOF-MS fingerprinted constituents from Daphne genkwa and their anti-inflammatory, anti-oxidant activities

被引：17
|
作者：
Du, Wen-Juan [1 ]
Ji, Jun [1 ]
Wang, Ling [1 ]
Lan, Xin-Yi [1 ]
Li, Jia [1 ]
Lei, Jun-Qiu [1 ]
He, Xin [2 ]
Zhang, Chun-Feng [1 ]
Huang, Wen-Zhe [3 ]
Wang, Zhen-Zhong [3 ]
Xiao, Wei [3 ]
Wang, Chong-Zhi [4 ,5 ]
Yuan, Chun-Su [4 ,5 ]
机构：
[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China
[2] Queens Univ Belfast, Sch Pharm, Belfast, Antrim, North Ireland
[3] Jiangsu Kan Pharmaceut Co Ltd, Lianyungang, Peoples R China
[4] Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA
[5] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA
来源：
BIOMEDICAL CHROMATOGRAPHY | 2017年 / 31卷 / 12期
基金：
中国国家自然科学基金;
关键词：
anti-inflammatory; anti-oxidant; canonical correlation analysis; Daphne genkwa; fingerprint-efficacy relationship; UPLC fingerprints; MASS-SPECTROMETRY; RAW264.7; CELLS; FLAVONOIDS; MACROPHAGES; INFLAMMATION; OFFICINALIS; INHIBITION; INJECTION; PRODUCTS; FORMULA;
D O I：
10.1002/bmc.4012
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Daphne genkwa Sieb.et Zucc. is a well-known medicinal plant. This study was designed to apply the ultra-high performance liquid chromatography system to establish a quality control method for D. genkwa. Data revealed that there were 15 common peaks in 10 batches of D. genkwa Sieb. Et Zucc. (Thymelaeaceae) from different provinces of China. On this basis, the fingerprint chromatogram was established to provide references for quality control. Afterwards, the chemical constitutions of these common peaks were analyzed using the UPLC-Q-TOF-MS system and nine of them were identified. In addition, LPS-stimulated RAW264.7 murine macrophages and DPPH assay were used to study the anti-inflammatory and anti-oxidation effects of D. genkwa. Then the fingerprint-efficacy relationships between UPLC fingerprints and pharmacodynamic data were studied with canonical correlation analysis. Analysis results indicated that the anti-inflammatory and anti-oxidation effects differed among the 10 D. genkwa samples owing to their inherent differences of chemical compositions. Taken together, this research established a fingerprint-efficacy relationship model of D. genkwa plant by combining the UPLC analytic technique and pharmacological research, which provided references for the detection of the principal components of traditional Chinese medicine on bioactivity.
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页数：9
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