MicroRNAs as Potential Biomarkers of Type 2 Diabetes Mellitus

被引：1
|
作者：
Tonyan, Z. N. [1 ]
Nasykhova, Y. A. [1 ,2 ]
Mikhailova, A. A. [1 ,2 ]
Glotov, A. S. [1 ,2 ]
机构：
[1] Ott Res Inst Obstet Gynecol & Reproductol, St Petersburg 199034, Russia
[2] St Petersburg State Univ, St Petersburg 199034, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2021年 / 57卷 / 07期
关键词：
miRNA; type 2 diabetes mellitus; biomarker; BLOOD MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; CIRCULATING MICRORNA-126; DIFFERENTIAL EXPRESSION; SERUM MICRORNA; MIR-126; PLASMA; MIR-375; INDIVIDUALS; ACTIVATION;
D O I：
10.1134/S1022795421060107
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs are small noncoding RNAs involved in post-transcriptional regulation of gene expression. In recent years, works demonstrating changes in the miRNA profile in tissues in type 2 diabetes mellitus were published. This work provides a systematic review of the results of 91 studies published from November 2009 to June 2020. Prospects for the use of miR-29a, -34a, -126, -144, -375 as potential biomarkers of type 2 diabetes mellitus are considered, and possible target genes of these miRNAs and mechanisms of the participation in glucose metabolism are also discussed.
引用
收藏
页码：764 / 777
页数：14
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