Effects of acute administration of methamphetamine on Narp mRNA in rat brain

被引:2
|
作者
Fukumoto, M [1 ]
Iwata, M [1 ]
Shinbori, C [1 ]
Hazama, GI [1 ]
Shirayama, Y [1 ]
Kawahara, R [1 ]
机构
[1] Tottori Univ, Fac Med, Dept Neuropsychiat, Yonago, Tottori 6838504, Japan
关键词
D O I
10.1080/13556219599222621
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Narp ( neuronal activity-regulated pentraxin) is a secreted immediate early gene product functioning as a cluster factor for the AMPA receptor subtype of glutamate receptors. This study was designed to examine the effects of acute administration of methamphetamine ( MAP) on the Narp gene in rat brain using reverse transcription - polymerase chain reaction (RT-PCR). Acute administration of MAP [4.6 mg/kg, intraperitoneally (i.p.)] increased Narp mRNA in the prefrontal cortex, whereas the same treatment with MAP decreased Narp mRNA in the hippocampus. Therefore, Narp gene could be involved in the MAP-induced effects.
引用
收藏
页码:257 / 259
页数:3
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