Transgenic mice overexpressing metallothionein are not resistant to adriamycin cardiotoxicity

被引：0
|
作者：
DiSilvestro, RA [1 ]
Liu, J [1 ]
Klaassen, CD [1 ]
机构：
[1] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66160
来源：
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY | 1996年 / 93卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metallothionein (MT) induction, particularly by bismuth, is proposed to protect against toxic side effects of chemotherapy drugs such as adriamycin. In contrast, transgenic mice, which overexpressed cardiac MT, and also had moderately high heart glutathione concentrations, were not resistant to adriamycin-induced cardiotoxicity. Cardiotoxicity was assessed by survival, fluid accumulation and lipid peroxidation, Thus, higher than normal heart MT concentrations do not necessarily protect against adriamycin cardiotoxicity.
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页码：163 / 170
页数：8
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