Bringing together history and the study of translation, this article focuses on Christian missionary activities in Eritrea and Ethiopia, with special reference to the nineteenth and early twentieth centuries. It presents and discusses their impact on the shaping and reshaping of cultures and identities in a dynamic interrelation with the African agenda. Though focusing on relatively recent events, this article also takes into account the traditions of evangelization and translation that populated the cultural and religious landscape of the region over a timespan of more than 16 centuries. Focusing on orally transmitted knowledge, written documents, the advent of printing in the area, and all the other activities which have made the dissemination of the missionaries' Christianity possible, this article aims to overcome the common assumption that colonialism stands as an absolute historical divide, and to suggest a revision of the notion of directionality typically applied to the observation of translation phenomena in Africa and other colonial contexts, whereby horizontality is associated with before and verticality with after the colonial period. Reflecting upon instances of multidirectional writing and translation processes from a historical perspective, with special reference to Christian missionary activities in the Horn of Africa, the ultimate aim of this article is to highlight the importance of interdisciplinary research and its great potential in casting light over events and practices which are still largely unexplored.