Highly Active Antiretroviral Therapy Versus Zidovudine for Prevention of Mother-to-Child Transmission in a Programmatic Setting, Botswana

被引：13
|
作者：
Dryden-Peterson, Scott [1 ,2 ,3 ]
Jayeoba, Oluwemimo [2 ]
Hughes, Michael D. [4 ]
Jibril, Haruna [5 ]
Keapoletswe, Koona [5 ]
Tlale, Josephine [5 ]
Modise, Taolo A. [2 ]
Asmelash, Aida [2 ]
Moyo, Sikhulile [2 ]
van Widenfelt, Erik [2 ]
Makhema, Joseph [2 ]
Essex, Max [2 ,3 ]
Shapiro, Roger L. [2 ,3 ]
Lockman, Shahin [1 ,2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA
[2] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana
[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[5] Minist Hlth, Dept HIV AIDS Prevent & Care, Gaborone, Botswana
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2011年 / 58卷 / 03期
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTION; PREGNANCY; REGIMENS; DISEASE; TRIAL; WOMEN; LOAD;
D O I：
10.1097/QAI.0b013e31822d4063
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Few studies have compared the programmatic effectiveness of the recommended strategies of antenatal highly active antiretroviral therapy (HAART) and zidovudine for prevention of mother-to-child transmission. We prospectively followed infants (93% formula fed) whose mothers who took either HAART (258 infants) or zidovudine (170 infants) during pregnancy in the Botswana national program. Overall, 10 infants (2.5%) acquired HIV-9 infants in the zidovudine group (5.5%, 95% confidence interval: 2.6% to 10.2%) and 1 infant in the HAART group (0.4%, 95% confidence interval: 0.0% to 2.2%). Maternal HAART was associated with decreased prevention of mother-to-child transmission (P = 0.001) and improved HIV-free survival (P = 0.040) compared with zidovudine (with or without single-dose nevirapine) in a programmatic setting.
引用
收藏
页码：353 / 357
页数：5
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