QSAR of apoptosis induction in various cancer cells

被引：15
|
作者：
Hansch, C [1 ]
Jazirehi, A
Mekapati, SB
Garg, R
Bonavida, B
机构：
[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA
[2] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 13期
关键词：
D O I：
10.1016/S0968-0896(03)00184-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In continuing our QSAR study of apoptosis, we consider in this report the action of phenolic compounds on Ramos cells (non-Hodgkins B-cell lymphoma): the effect of O-8-thapsigargin analogues on human prostate cancer cells, Tsu-Pr-1 and the induction of apoptosis of a complex set of congeners on human fibrosarcoma cells HT 1080. The human prostate cancer cells activity is very similar to that of the Ramos cells. While the QSAR for the fibrosarcoma cells resembles that of our earlier study with L1210 leukemia cells. The two different types of QSAR suggest at least two quite different types of receptors for the induction of apoptosis. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3015 / 3019
页数：5
相关论文
共 50 条
  • [1] Mechanism of the induction of apoptosis in cancer cells
    Nakaya, K
    [J]. SEIKAGAKU, 1996, 68 (12): : 1808 - 1812
  • [2] Apoptosis induction in ovarian cancer cells
    Kuebler, K.
    Poelcher, M.
    Kuhn, W.
    Hartmann, G.
    Barchet, W.
    [J]. GEBURTSHILFE UND FRAUENHEILKUNDE, 2008, 68 : S78 - S78
  • [3] Induction of apoptosis in breast cancer cells by TPA
    Yiwei Li
    Mahbubur Bhuiyan
    Ramzi M Mohammad
    Fazlul H Sarkar
    [J]. Oncogene, 1998, 17 : 2915 - 2920
  • [4] Induction of apoptosis in breast cancer cells by TPA
    Li, YW
    Bhuiyan, M
    Mohammad, RM
    Sarkar, FH
    [J]. ONCOGENE, 1998, 17 (22) : 2915 - 2920
  • [5] Apoptosis induction in cancer cells by ultrasound exposure
    Watanabe, A
    Kawai, K
    Sato, T
    Nishimura, H
    Kawashima, N
    Takeuchi, S
    [J]. JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS, 2004, 43 (5B): : 3245 - 3248
  • [6] Growth of Colorectal Cancer Cells and Induction of Apoptosis
    Green, Rachel
    Ali, Nawab
    [J]. BIOLOGY, NANOTECHNOLOGY, TOXICOLOGY, AND APPLICATIONS: PROCEEDINGS OF THE 5TH BIONANOTOX AND APPLICATIONS INTERNATIONAL RESEARCH CONFERENCE, 2011, 1326 : 50 - 51
  • [7] Induction of Apoptosis by Deinoxanthin in Human Cancer Cells
    Choi, Yong-Ji
    Hur, Jung-Mu
    Lim, Sangyong
    Jo, Minho
    Kim, Dong Ho
    Choi, Jong-Il
    [J]. ANTICANCER RESEARCH, 2014, 34 (04) : 1829 - 1835
  • [8] Induction of apoptosis by gallic acid in lung cancer cells
    Ohno, Y
    Fukuda, K
    Takemura, G
    Toyota, M
    Watanabe, M
    Yasuda, N
    Qiu, XB
    Maruyama, R
    Akao, S
    Gotou, K
    Fujiwara, T
    Fujiwara, H
    [J]. ANTI-CANCER DRUGS, 1999, 10 (09) : 845 - 851
  • [9] Induction of apoptosis in gastric cancer cells by neoadjuvant chemotherapy
    Kato, M
    Hirai, H
    Imano, M
    Nishikawa, M
    Nakayama, T
    Izutani, R
    Asano, S
    Kawamura, S
    Kuroda, D
    Fujiie, S
    Nakai, A
    Ohyanagi, H
    [J]. 17TH INTERNATIONAL CANCER CONGRESS, VOL 1 AND 2, 1998, : 935 - 938
  • [10] GML sensitizes cancer cells to Taxol by induction of apoptosis
    Yasutoshi Kimura
    Tomohisa Furuhata
    Takayuki Shiratsuchi
    Hiroyuki Nishimori
    Koichi Hirata
    Yusuke Nakamura
    Takashi Tokino
    [J]. Oncogene, 1997, 15 : 1369 - 1374
12345