The ARUBA Trial Current Status, Future Hopes

被引：55

作者：

Mohr, J. P. ^{[1
,2
]}

Moskowitz, Alan J.

Stapf, Christian ^{[4
]}

Hartmann, Andreas ^{[5
]}

Lord, Karen ^{[1
,6
]}

Marshall, Steven M. ^{[6
]}

Mast, Henning ^{[7
]}

Moquete, Ellen ^{[3
]}

Moy, Claudia Scala ^{[8
]}

Parides, Michael ^{[3
]}

Pile-Spellman, John ^{[1
]}

Salman, Rustam Al-Shahi ^{[9
]}

Weinberg, Alan ^{[3
]}

Young, William L. ^{[10
]}

Estevez, Alejandrina ^{[3
]}

Kureshi, Inam ^{[11
]}

Brisman, Jonathan L.

机构：

[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[2] Doris & Stanley Tananbaum Stroke Ctr, Neurol Inst, New York, NY 10032 USA

[3] Mt Sinai Sch Med, New York, NY USA

[4] Hop Lariboisiere, F-75475 Paris, France

[5] Klinikum Frankfurt Oder, Frankfurt, Germany

[6] Columbia Univ, New York, NY USA

[7] Klin Im Pk, Zurich, Switzerland

[8] NINDS, Bethesda, MD 20892 USA

[9] Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland

[10] Univ Calif San Francisco, San Francisco, CA 94143 USA

[11] Hartford Hosp, Hartford, CT 06115 USA

来源：

STROKE | 2010年 / 41卷 / 08期

关键词：

arteriovenous malformations; endovascular treatment; neuroradiology; neurosurgery; radiotherapy; randomized controlled trials; BRAIN ARTERIOVENOUS-MALFORMATIONS; INTRACRANIAL VASCULAR MALFORMATIONS; NATURAL-HISTORY; EXTRACRANIAL ARTERIES; FOLLOW-UP; HEMORRHAGE; DETERMINANTS; RISK; ENDARTERECTOMY; EMBOLIZATION;

D O I：

10.1161/STROKEAHA.110.580274

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history. (Stroke. 2010; 41: e537-e540.)

引用

页码：E537 / E540

页数：4

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