Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization

被引：27
|
作者：
Dong, Xichang [1 ]
Hu, Yumin [1 ]
Xiao, Tiebo [1 ]
Zhou, Lei [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 49期
基金：
中国国家自然科学基金;
关键词：
REGIOSELECTIVE SYNTHESIS; BEARING METHOXYCARBONYL; OXIDATIVE CYCLIZATION; PHOTOREDOX CATALYSIS; ELECTRON-TRANSFER; METAL-FREE; GENERATION; TRIFLUOROMETHYLATION; CATIONS; ALKYNES;
D O I：
10.1039/c5ra05967d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A visible-light induced intramolecular radical cyclization of N-[2(alkynyl)phenyl] trifluoroacetimidoyl chlorides is described. The reaction allows the rapid construction of diverse 2-trifluoromethyl-3-acylindoles in a sequential C-C and C-O bond formation process under mild conditions.
引用
收藏
页码：39625 / 39629
页数：5
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