Several forthcoming wireless telecommunication systems will use electromagnetic frequencies at millimeter waves (MMWs), and technologies developed around the 60-GHz band will soon know a widespread distribution. Free nerve endings within the skin have been suggested to be the targets of MMW therapy which has been used in the former Soviet Union. So far, no studies have assessed the impact of MMW exposure on neuronal metabolism. Here, we investigated the effects of a 24-h MMW exposure at 60.4 GHz, with an incident power density (IPD) of 5 mW/cmA(2), on the dopaminergic turnover of NGF-treated PC12 cells. After MMW exposure, both intracellular and extracellular contents of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were studied using high performance liquid chromatography. Impact of exposure on the dopamine transporter (DAT) expression was also assessed by immunocytochemistry. We analyzed the dopamine turnover by assessing the ratio of DOPAC to DA, and measuring DOPAC accumulation in the medium. Neither dopamine turnover nor DAT protein expression level were impacted by MMW exposure. However, extracellular accumulation of DOPAC was found to be slightly increased, but not significantly. This result was related to the thermal effect, and overall, no evidence of non-thermal effects of MMW exposure were observed on dopamine metabolism.
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Tsumoto, Hiroki
Kawahara, Syo
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Kawahara, Syo
Fujisawa, Yuki
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Fujisawa, Yuki
Suzuki, Takayoshi
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Suzuki, Takayoshi
Nakagawa, Hidehiko
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Nakagawa, Hidehiko
Kohda, Kohfuku
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Musashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan
Kohda, Kohfuku
Miyata, Naoki
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Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanMusashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan