Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma

被引：35
|
作者：
Masmoudi, Amine [1 ]
Toumi, Nabil
Khanfir, Afef
Kallel-Slimi, Lamia
Daoud, Jamel
Karray, Hela
Frikha, Mounir
机构：
[1] Habib Bourguiba Hosp, Dept Med Oncol, Sfax 3029, Tunisia
[2] Habib Bourguiba Hosp, Dept Radiotherapy, Sfax 3029, Tunisia
[3] Habib Bourguiba Hosp, Dept Microbiol, Sfax 3029, Tunisia
来源：
CANCER TREATMENT REVIEWS | 2007年 / 33卷 / 06期
关键词：
nasopharyngeal cancer; Epstein-Barr virus; adoptive immunotherapy; vaccination;
D O I：
10.1016/j.ctrv.2007.04.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epstein-Barr virus (EBV) is constantly present in undifferentiated and poorly-differentiated nasopharyngeal cancer. Thus, tumour-associated viral antigens are potential targets for immunotherapy. Recently, both preclinical and early clinical studies have shown that various strategies can enhance EBV-specific immunity. Moreover, significant anti-tumour effect has been observed, and was generally correlated with biological response. The present review discusses the rational for EBV-targeted immunotherapy and summarises the latest developments in this area. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：499 / 505
页数：7
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