Copper catalyzed one-pot difluoroalkylation and lactonization of unsaturated carboxylic acids

被引：21
|
作者：
Yuan, Fangyuan [1 ]
Zhou, Sen [1 ]
Yang, Yanyan [1 ]
Guo, Minjie [2 ]
Tang, Xiangyang [1 ]
Wang, Guangwei [1 ]
机构：
[1] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Sch Sci, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Inst Mol Design & Synth, Tianjin 300072, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 22期
关键词：
GAMMA-BUTYROLACTONES; ALKENES; LACTONES; OXYTRIFLUOROMETHYLATION; FUNCTIONALIZATION;
D O I：
10.1039/c8qo00940f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
gamma-Lactone is an important scaffold found in many natural products and biologically active compounds. A strategy for one-pot bi-functionalization of unsaturated carboxylic acids to afford difluoroalkylated -lactones using a Cu(i) catalyst has been reported. This protocol has the advantages of mild reaction conditions, a low-cost catalyst, and a broad substrate scope, which provides a convenient strategy for synthesizing various difluoroalkylated -lactones.
引用
收藏
页码：3306 / 3309
页数：4
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