Bupropion SR vs placebo for smoking cessation in health care professionals

被引：25
|
作者：
Zellweger, JP
Boeleskei, PL
Carrozzi, L
Sepper, R
Sweet, R
Hider, AZ
机构：
[1] Univ Lausanne, Med Poliklin, CH-10011 Lausanne, Switzerland
[2] Inst Smokers Counseling & Smoking Cesat, Munich, Germany
[3] Univ Pisa, Cardiac & Thorac Dept, Pisa, Italy
[4] N Estonian Reg Hosp, Tallinn, Estonia
[5] GlaxoSmithKline Res & Dev Ltd, Greenford, Middx, England
来源：
AMERICAN JOURNAL OF HEALTH BEHAVIOR | 2005年 / 29卷 / 03期
关键词：
bupropion SR; healthcare professionals; smoking cessation;
D O I：
10.5993/AJHB.29.3.5
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To evaluate bupropion SR for smoking cessation in physicians and nurses. Methods: This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. The participants were followed for 52 weeks. Results: Bupropion SR was superior to placebo (50% vs 40%, P=0.013) on the 4-week primary outcome variable. Due to a high placebo response in this health care population, statistical differences were not maintained after treatment was discontinued. Conclusions: Bupropion SR is effective and well tolerated in health care professionals. Relapse prevention measures are needed to attain long-term abstinence.
引用
收藏
页码：240 / 249
页数：10
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