DXA-based variables and osteoporotic fractures in Lebanese postmenopausal women

Introduction: The aim of this study was to assess DXA-based variables (bone mineral density, bone mineral apparent density, compressive strength index of the femoral neck and trabecular bone score) in Lebanese postmenopausal women having presented a previous fracture. Materials and methods: One thousand Lebanese postmenopausal women between 45 and 89 years participated in this study. The women were recruited by advertisements offering bone mineral density measurements at a reduced cost. Subjects with previous history of radiotherapy or chemotherapy were excluded. Informed written consent was obtained from all the participants. Results: Femoral neck compressive strength index (FN CSI) was significantly (P < 0.001) associated with the presence of fracture using a simple logistic regression (odds ratio = 0.51 [0.385-0.653]). When a multivariate logistic regression analysis was performed with the presence of fracture as a dependent variable and each of age, FN BMD and FN CSI as independent variables, only FN BMD (P = 0.005) and FN CSI (A= 0.004) were found to be associated with the presence of fracture. Conclusion: This study suggests that FN CSI is associated with history of osteoporotic fractures in postmenopausal women. The use of FN CSI in clinical practice may help to identify patients with high risk of fracture. Level of evidence: Epidemiological study, level IV. (C) 2014 Elsevier Masson SAS. All rights reserved.