Improved one-pot synthesis of 6-methylpurines under microwave irradiation

被引：3
|
作者：
Guo, Hai-Ming [1 ]
Mao, Zhi-Jie [1 ]
Niu, Hong-Ying [2 ]
Wang, Dong-Chao [1 ]
Zhang, Gui-Sheng [1 ]
Qu, Gui-Rong [1 ]
机构：
[1] Henan Normal Univ, Coll Chem & Environm Sci, Key Lab Green Chem Media & React, Minist Educ, Xinxiang 453007, Peoples R China
[2] Sch Chem & Chem Engn, Henan Inst Sci & Technol, Xinxiang 453003, Peoples R China
来源：
ARKIVOC | 2010年
关键词：
Microwave; one-pot reaction; 6-methylpurine; CROSS-COUPLING REACTIONS; EFFICIENT SYNTHESIS; CYTOSTATIC ACTIVITY; ASSISTED SYNTHESIS; ORGANIC-SYNTHESIS; PURINE-BASES; ANALOGS; NUCLEOSIDES; (PURIN-6-YL)ACETATES; 6-HALOPURINES;
D O I：
10.3998/ark.5550190.0011.928
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient method for direct synthesis of 6-methylpurines was developed through SNAr-based addition reactions between various 6-halopurine derivatives and ethyl acetoacetate with assistance of microwave irradiation, which underwent direct coupling reaction, in situ deacetylation and decarboxylation to yield 6-methylated purines in high to excellent yields within 10 min.
引用
收藏
页码：300 / 307
页数：8
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